Bioinspired design of an artificial peroxidase: introducing key residues of native peroxidases into F43Y myoglobin with a Tyr-heme cross-link

文献类型： 外文期刊

第一作者： Liao, Fei

作者： Liao, Fei;Luo, Jie;Lin, Ying-Wu;Xu, Jia-Kun;Wang, Xiao-Juan;Gao, Shu-Qin;Lin, Ying-Wu

作者机构：

期刊名称：DALTON TRANSACTIONS （ 影响因子：4.39； 五年影响因子：4.07 ）

ISSN： 1477-9226

年卷期： 2020 年 49 卷 16 期

页码：

收录情况： SCI

摘要： Inspired by the structural features of native peroxidases, an artificial peroxidase was rationally designed using F43Y myoglobin with a Tyr-heme cross-link by further introduction of key residues, including both a distal Arg and a Trp close to the heme group, which exhibits an enhanced peroxidase activity similar to the most efficient native horseradish peroxidase. This study provides a simple approach for design of artificial heme enzymes by the combination of catalytic elements of native enzymes with the post-translational modifications of heme proteins.

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