Identification of muscle-specific candidate genes in Simmental beef cattle using imputed next generation sequencing

文献类型： 外文期刊

第一作者： Bordbar, Farhad

作者： Bordbar, Farhad;Zhu, Bo;Wang, Zezhao;Xu, Lei;Chang, Tianpeng;Xu, Ling;Zhang, Lupei;Gao, Huijiang;Xu, Lingyang;Li, Junya;Jensen, Just;Du, Min

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2019 年 14 卷 10 期

页码：

收录情况： SCI

摘要： Genome-wide association studies (GWAS) have commonly been used to identify candidate genes that control economically important traits in livestock. Our objective was to detect potential candidate genes associated mainly with muscle development traits related to dimension of hindquarter in cattle. A next generation sequencing (NGS) dataset to imputed to 12 million single nucleotide polymorphisms (SNPs) (from 1252 Simmental beef cattle) were used to search for genes affecting hindquarter traits using a linear, mixed model approach. We also used haplotype and linkage disequilibrium blocks to further support our identifications. We identified 202 significant SNPs in the bovine BTA4 chromosome region associated with width of hind leg, based on a stringent statistical threshold (p = 0.05/effective number of SNPs identified). After exploring the region around these SNPs, we found candidate genes that were potentially related to the associated markers. More importantly, we identified a region of approximately 280 Kb on the BTA4 chromosome that harbored several muscle specific candidate genes, genes to be in a potential region for muscle development. However, we also found candidate gene SLC13A1 on BTA4, which seems to be associated with bone disorders (such as chondrodysplasia) in Simmental beef cattle.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序