Ethylicin Prevents Potato Late Blight by Disrupting Protein Biosynthesis of Phytophthora infestans

文献类型： 外文期刊

第一作者： Zhang, Shumin

作者： Zhang, Shumin;Zhang, Meiquan;Dong, Pan;Ren, Maozhi;Zhang, Shumin;Wang, Hanyan;Khalid, A. Rehman;Li, Linxuan;Ren, Maozhi;Chen, Yang

作者机构：

关键词： Phytophthora infestans; ethylicin; potato late blight; proteomics; ribosome; metabonomics; protein biosynthesis

期刊名称：PATHOGENS （ 影响因子：3.492； 五年影响因子：4.066 ）

ISSN：

年卷期： 2020 年 9 卷 4 期

页码：

收录情况： SCI

摘要： Phytophthora infestans, the causal agent of potato late blight, triggered the devastating Great Irish Famine that lasted from 1845 to 1852. Today, it is still the greatest threat to the potato yield. Ethylicin is a broad-spectrum biomimetic-fungicide. However, its application in the control of Phytophthora infestans is still unknown. In this study, we investigated the effects of ethylicin on Phytophthora infestans. We found that ethylicin inhibited the mycelial growth, sporulation capacity, spore germination and virulence of Phytophthora infestans. Furthermore, the integrated analysis of proteomics and metabolomics indicates that ethylicin may inhibit peptide or protein biosynthesis by suppressing both the ribosomal function and amino acid metabolism, causing an inhibitory effect on Phytophthora infestans. These observations indicate that ethylicin may be an anti-oomycete agent that can be used to control Phytophthora infestans.

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