Construction and characterization of avermectin B-2 solid nanodispersion

文献类型： 外文期刊

第一作者： Cui, Bo

作者： Cui, Bo;Gao, Fei;Zeng, Zhanghua;Wang, Chunxin;Wang, Yan;Sun, Changjiao;Zhao, Xiang;Guo, Liang;Shen, Yue;Liu, Guoqiang;Cui, Haixin

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2020 年 10 卷 1 期

页码：

收录情况： SCI

摘要： Poorly water-soluble pesticide compounds are difficult to be formulated as environmentally friendly formulations with high efficacy. For the conventional formulations, more than 50% of pesticides are lost during application due to the decomposition of active ingredient, dust drift and running off. Therefore, there is an urgent need to construct a novel formulation for improving the bioavailability of pesticides. The avermectin B-2 solid nanodispersion was developed by self-emulsifying and solidification technology. The average particle size, surface tension and contact angle on cabbage leaves of the solid nanodispersion were 35.3nm, 36.6 mN/m and 58 degrees, respectively. The toxicities of the nanoformulation against diamondback moths and root-knot nematode were more than 1.7 times that of conventional emulsion in water and water dispersible granule. This investigation demonstrated that for foliage-applied pesticides, the formulation bioavailability had positive correlation with wettability which was negatively correlated with surface tension and contact angle. This study provides an easy and scalable technique to construct the effective and environmentally friendly nanoformulations. The toxicity improvement of the solid nanodispersion will significantly reduce dosage and environmental pollution of pesticide. The clarified relationship between formulation parameters and biological activity will contribute to the design and construction of novel pesticide formulations.

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