Design, synthesis and bioactivity evaluation of novel thioether derivatives containing a sulfonohydrazide moiety

文献类型： 外文期刊

第一作者： Li, Pei

作者： Li, Pei;Wang, Xiang;Zhou, Junliang;Liu, Yan

作者机构：

关键词： Synthesis; antibacterial activity; thioether; sulfonohydrazide

期刊名称：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS （ 影响因子：1.082； 五年影响因子：0.859 ）

ISSN： 1042-6507

年卷期： 2020 年 195 卷 12 期

页码：

收录情况： SCI

摘要： A series of novel thioether derivatives containing a sulfonohydrazide moiety were synthesized and determined using(1)H NMR,C-13 NMR, HRMS, and elemental analysis. Theirin vitroantibacterial activities againstXanthomonas oryzaepv.oryzae(Xoo) andXanthomonas axonopodispv.citri(Xac) were investigated by performing turbidimeter test. Bioassay results showed that some of the target compounds revealed moderate to good antibacterial activities againstXooandXac. Especially,N'-(2-(ethylthio)acetyl)-4-fluorobenzenesulfonohydrazide (4p) revealed the best bioactivities againstXooandXac, with the 50% effective concentration (EC50) values of 13.75 and 18.56 mu g/mL, respectively, which were even better than those of thiodiazole copper and bismerthiazol.

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