Application of N-Acylimidazoles in the Claisen Condensation Reaction

文献类型： 外文期刊

第一作者： Quan, Haiyuan

作者： Quan, Haiyuan;Wang, Liuyang;Wang, Zhinan;Mei, Xiangdong;Ning, Jun;She, Dongmei

作者机构：

关键词： Claisen condensation; isotopic labeling; ketones; beta-keto acyl imidazoles; beta-keto esters

期刊名称：CHEMISTRYSELECT （ 影响因子：2.109； 五年影响因子：2.054 ）

ISSN： 2365-6549

年卷期： 2020 年 5 卷 24 期

页码：

收录情况： SCI

摘要： The Claisen condensation reaction is a classical method used for the formation of C-C bonds. Homo- and cross-Claisen condensation reactions are usually carried out using a Ti(IV)-based reagent at ultra-low-temperatures. In this report, intermediate beta-keto acyl imidazoles were synthesised using a sodium imidazolide-catalysed homo- and cross-condensation reaction ofN-acyl imidazoles performed under mild conditions and subsequently used to prepare a range of beta-keto esters and ketones via alcoholysis or hydrolysis. This method is particularly suitable for the synthesis of isotopically-labelled acetylacetic ester compounds.N-acyl imidazole compounds are useful reactants for the Claisen condensation reaction.

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