Convergent genomic signatures of high-altitude adaptation among domestic mammals

文献类型： 外文期刊

第一作者： Wu, Dong-Dong

作者： Wu, Dong-Dong;Wang, Ming-Shan;Zeng, Lin;Liu, He-Qun;Xie, Hai-Bing;Ma, Yun-Fei;Irwin, David M.;Dong, Yang;Wang, Wen;Shi, Peng;Zhang, Ya-Ping;Yan, Da-Wei;Kong, Xiao-Yan;Yang, Shu-Li;Dong, Xin-Xing;Gou, Xiao;Yang, Cui-Ping;Shen, Qiu-Shuo;Jiang, Li-Ping;Xiao, Xiao;Li, Ming;Chen, Yong-Bin;Dong, Kun-Zhe;Ma, Yue-Hui;Wu, Dong-Dong;Yang, Cui-Ping;Wang, Ming-Shan;Shen, Qiu-Shuo;Jiang, Li-Ping;Zeng, Lin;Liu, He-Qun;Xie, Hai-Bing;Ma, Yun-Fei;Dong, Yang;Wang, Wen;Shi, Peng;Chen, Yong-Bin;Zhang, Ya-Ping;Li, Yan;Zhang, Ya-Ping;Fan, Song-Qing;Chu, Shu-Zhou;Esmailizadeh, Ali;Irwin, David M.;Wu, Dong-Dong;Li, Hai-Peng;Chen, Yong-Bin;Zhang, Ya-Ping;Hao, Zi-Qian;Li, Hai-Peng

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关键词： high altitude; Tibetan Plateau; genome; convergent evolution; domestic animals

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：17.275； 五年影响因子：17.584 ）

ISSN： 2095-5138

年卷期： 2020 年 7 卷 6 期

页码：

收录情况： SCI

摘要： Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.

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