A fungal effector and a rice NLR protein have antagonistic effects on a Bowman-Birk trypsin inhibitor

文献类型： 外文期刊

第一作者： Zhang, Chongyang

作者： Zhang, Chongyang;Fang, Hong;Shi, Xuetao;He, Feng;Wang, Ruyi;Fan, Jiangbo;Wang, Jiyang;Zhou, Xueping;Ning, Yuese;Zhang, Chongyang;Fan, Jiangbo;Bai, Pengfei;Park, Chan-Ho;Bellizzi, Maria;Wang, Guo-Liang

作者机构：

关键词： Magnaporthe oryzaeeffector; rice; Bowman-Birk trypsin inhibitor; NLR protein; plant immunity

期刊名称：PLANT BIOTECHNOLOGY JOURNAL （ 影响因子：9.803； 五年影响因子：9.555 ）

ISSN： 1467-7644

年卷期： 2020 年 18 卷 11 期

页码：

收录情况： SCI

摘要： Bowman-Birk trypsin inhibitors (BBIs) play important roles in animal and plant immunity, but how these protease inhibitors are involved in the immune system remains unclear. Here, we show that the rice (Oryza sativa) BBI protein APIP4 is a common target of a fungal effector and an NLR receptor for innate immunity. APIP4 exhibited trypsin inhibitor activityin vitroandin vivo. Knockout ofAPIP4in rice enhanced susceptibility, and overexpression ofAPIP4increased resistance to the fungal pathogenMagnaporthe oryzae. TheM. oryzaeeffector AvrPiz-t interacted with APIP4 and suppressed APIP4 trypsin inhibitor activity. By contrast, the rice NLR protein Piz-t interacted with APIP4, enhancing APIP4 transcript and protein levels, and protease inhibitor activity. Our findings reveal a novel host defence mechanism in which a host protease inhibitor targeted by a fungal pathogen is protected by an NLR receptor.

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