Hepatic oxidative stress,DNAdamage and apoptosis in adult zebrafish following sub-chronic exposure toBDE-47 andBDE-153

文献类型： 外文期刊

第一作者： Meng, Shunlong

作者： Meng, Shunlong;Chen, Xi;Chen, Jiazhang;Meng, Shunlong;Chen, Xi;Chen, Jiazhang;Gyimah, Eric;Xu, Hai

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关键词： apoptosis-related genes; DNA damage; hepatocyte; oxidative stress; zebrafish

期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）

ISSN： 1520-4081

年卷期： 2020 年 35 卷 11 期

页码：

收录情况： SCI

摘要： Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2 ',4,4 '-tetrabrominateddiphenyl ether (BDE-47) and 2,2 ',4,4 ',5,5 '-hexabromodiphenyl ether (BDE-153) exposure on the induction of hepatic oxidative stress, DNA damage, and the expression of apoptosis-related genes in adult zebrafish were investigated. The activities of antioxidant enzymes, such as catalase and superoxide dimutase, significantly increased when adult zebrafish was exposed to various concentrations of BDE-47 and BDE-153 for 7 and 15 days. BDE-47 and BDE-153 elicited significant alterations in zebrafish 7-Ethoxyresorufin-O-deethylase activity at 3, 7, or 15 days of exposure. In addition, the significant increase in comet assay parameters of zebrafish hepatocytes in a concentration-dependent manner indicated BDE-47 and BDE-153 induced DNA damage, probably due to observed oxidative stress. Furthermore, a monotonically upregulation ofp53andCaspase3, which are apoptotic-regulated genes, and decreased expression ratio of the anti-apoptotic B-cell lymphoma/leukaemia-2 and Bcl2-associated X protein genes for all BDE-47 and BDE-153 treatments at 7 and 15 days indicated apoptosis induction in zebrafish liver. Our findings help elucidate the mechanisms of BDE-47- and BDE-153-induced toxicity in zebrafish hepatocytes.

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