Synthesis and biological evaluation of 2-(4-substituted benzene-1-sulfonyl)-N'-(substituted-1-sulfonyl)acetohydrazide as antibacterial agents

文献类型： 外文期刊

第一作者： Li, Pei

作者： Li, Pei;Wang, Xiang;Zhou, Junliang;Liu, Yan

作者机构：

关键词： Sulfone; Sulfonohydrazide; Synthesis; Antibacterial activity

期刊名称：CHEMICAL PAPERS （ 影响因子：2.097； 五年影响因子：1.831 ）

ISSN： 2585-7290

年卷期： 2020 年 74 卷 12 期

页码：

收录情况： SCI

摘要： In this study, a series of new sulfone derivatives containing a sulfonohydrazide moiety were synthesized and their structures were determined using(1)H NMR,C-13 NMR, and HRMS. Then, the in vitro antibacterial activities againstXanthomonas oryzaepv.oryzae(Xoo) andXanthomonas axonopodispv.citri(Xac) were evaluated by performing turbidimeter test. Bioactivity results showed that compound 2-(4-fluorobenzene-1-sulfonyl)-N '-(4-fluorobenzene-1-sulfonyl)acetohydrazide (5g) revealed the best antibacterial activities againstXooandXac, with the 50% effective concentration (EC50) values of 25 and 36 mu g/mL, respectively, which were superior to those of thiodiazole copper (110 and 230 mu g/mL, respectively) and bismerthiazol (84 and 146 mu g/mL, respectively).

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