RAI14 in the blood feather regulates chicken pigmentation

文献类型： 外文期刊

第一作者： Adetula, Adeyinka Abiola

作者： Adetula, Adeyinka Abiola;Liu, Xiaolei;Yang, Liubin;Fang, Chengchi;Li, Shijun;Adetula, Adeyinka Abiola;Adetula, Adeyinka Abiola;Yu, Hui;Li, Hua

作者机构：

期刊名称：ARCHIVES ANIMAL BREEDING （ 影响因子：1.528； 五年影响因子：1.723 ）

ISSN： 0003-9438

年卷期： 2020 年 63 卷 2 期

页码：

收录情况： SCI

摘要： A genome-wide association study (GWAS) was performed on a resource family consisting of white and colored chickens for identification of genes related to plumage coloration using the Fixed and random model Circulating Probability Unification (FarmCPU) package. GWAS identified three chromosomal single-nucleotide polymorphisms (SNPs), demonstrating the polygenic basis of plumage phenotypes. Herein, retinoic acid-induced protein 14 (RAI14), a developmentally regulated gene that encodes a protein containing many ankyrin repeats, was identified as a candidate gene involved in plumage color. In this study, mRNA expression profiles of chicken RAI14 were determined, indel (insertion-deletion) variants were identified, and their association was analyzed in white and colored chickens. RAI14 mRNA was expressed in all tissues tested (brain, spleen, liver, heart, oviduct, kidney, lung, pituitary gland, ovary, muscle, feather bulb, and skin). A relatively high RAI14 expression in white feather bulb compared to colored feather bulb (P <0.01) indicated a potential association with plumage color. Additionally, statistical analysis revealed that a 4 bp indel genetic variation in RAI14 was associated with plumage phenotypes (P <0.01). Together, our analysis of the identification of the RAI14 gene will enable us to understand the genetic mechanisms behind chicken pigmentation.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序