Development of Facile and Selective Fluorescent Probe for Physiological Phosphates based on Aggregation-induced Emission

文献类型： 外文期刊

第一作者： Jiao, Zhe

作者： Jiao, Zhe;Jiao, Zhe;Long, Xiaojuan;Lu, Yingfang;Guo, Zongning;Huang, Xuelin;Song, Chao;Song, Chao

作者机构：

关键词： AIEgens; Physiological phosphates; Sensor array; Fluorescence; PEI

期刊名称：JOURNAL OF FLUORESCENCE （ 影响因子：2.217； 五年影响因子：1.906 ）

ISSN： 1053-0509

年卷期： 2020 年 30 卷 5 期

页码：

收录情况： SCI

摘要： In this work, two new fluorescence chemosensors 2-(4-(1,2,2-triphenylvinyl)phenoxy) acetic acid (TPE-COOH) and 2,2'-(((1,2-diphenylethane-1,2-diyl)bis(4,1-phenylene))bis(oxy))diacetic acid (TPE-(COOH)(2)) were synthesized and applied for the facile detection of physiological phosphates. Due to the aggregation-induced emission (AIE) character, the emission can be turned on after label free interaction with polyethyleneimine (PEI). When the physiological phosphates were introduced to the system, the AIEgens/PEI complex was dissociated due to stronger electrostatic interaction between PEI and phosphates, which resulted in the significant fluorescence quenching of AIEgens. As the four kinds of phosphates cytidine-5'-diphosphate disodium salt (CDP), adenosine-5 (ADP), sodium pyrophosphate (PPi) and guanosine-5'-diphosphate disodium salt (GDP) had different interaction with PEI, also the TPE-COOH and TPE-(COOH)(2)had different interaction with PEI, the fluorescence quenching effect was distinct for four phosphates. The unique pattern of fluorescence variations was differentiated by chemometric methods including principal component analysis and linear discriminant analysis. The robustness of the sensor array was proved by discrimination of four kinds of phosphates in serum samples with different concentrations, and the discrimination capacity was not influenced in complicated samples

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