A Novel Mechanism of bta-miR-210 in Bovine Early Intramuscular Adipogenesis
文献类型: 外文期刊
第一作者: Ren, Ling
作者: Ren, Ling;Li, Qian;Hu, Xin;Xing, Yishen;Wang, Yahui;Li, Junya;Zhang, Lupei;Hu, Xin;Yang, Qiyuan;Du, Min;Du, Min
作者机构:
关键词: bta-miR-210; bovine; progenitor cells; intramuscular adipogenesis; WISP2
期刊名称:GENES ( 影响因子:4.096; 五年影响因子:4.339 )
ISSN:
年卷期: 2020 年 11 卷 6 期
页码:
收录情况: SCI
摘要: Intramuscular fat (IMF) is one of the major factors determining beef quality. IMF formation is influenced by multiple conditions including genetic background, age and nutrition. In our previous investigation, bta-miR-210 was found to be increased during adipogenesis using miRNA-seq. In this study, we validated the upregulation of bta-miR-210 in platelet-derived growth factor receptor alpha positive (PDGFR alpha(+)) progenitor cells during adipogenic differentiation in vitro. To investigate its role in adipogenesis, bta-miR-210 mimics were introduced into progenitor cells, which resulted in enhanced intracellular lipid accumulation. Accordingly, the expression of adipocyte-specific genes significantly increased in the bta-miR-210 mimic group compared to that in the negative control group (p< 0.01). Dual-luciferase reporter assays revealed thatWISP2is a target of bta-miR-210.WISP2knockdown enhanced adipogenesis. In conclusion, bta-miR-210 positively regulates the adipogenesis of PDGFR alpha(+)cells derived from bovine fetal muscle by targetingWISP2.
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