Safety evaluation of aqueous extracts of Sanghuangporus vaninii fruiting body in Sprague-Dawley rats

文献类型： 外文期刊

第一作者： Huo, Jinxi

作者： Huo, Jinxi;Sun, Yuqing;Zhong, Shi;Li, Yougui;Zhu, Jianxun;Yang, Ruchun;Xia, Lijuan;Wang, Jiahong;Zhang, Majuan

作者机构：

关键词： acute toxicity; aqueous extracts; repeated dose toxicity; safety evaluation; Sanghuangporus vaninii

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

年卷期： 2020 年 8 卷 9 期

页码：

收录情况： SCI

摘要： Sanghuangporus vaninii, called "Sanghuang," is orally used for health care, tumor, and inflammation treatment in Asia. However, the safety ofS. vaniniihas not been evaluated. The major compounds analysis showed that aqueous extracts ofS. vaniniifruiting body were rich in polysaccharides, nucleotides, and polyphenols. Then, the aqueous was given orally to Sprague-Dawley rats for toxical test. In acute toxicity study, the maximum tolerated dose was 21 g/kg. In 17-week repeated dose toxicity experiment, all rats had no abnormal reaction among control group, low dose group (0.15 g/kg) and middle dose group (1.00 g/kg). At high dose group (6.00 g/kg), the feces began to darken on 16th day (D16), and turned to drug stained stool on D21, all rats recovered on the 3rd day (D92) of recovery period. During the whole experiment, there were no animal death and no treatment-related changes in any of the parameters under the all doses. These results indicated the No-Observed Adverse Effect Level of aqueous extract ofS. vaniniifruiting body was 1.0 g/kg.

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