Mixtures of Tea andCitrus maxima(pomelo) Alleviate Lipid Deposition in HepG2 Cells Through the AMPK/ACC Signaling Pathway

文献类型： 外文期刊

第一作者： An, Ran

作者： An, Ran;Li, Qiu-Hua;Lai, Xing-Fei;Zhang, Wen-Ji;Chen, Ruo-Hong;Cao, Jun-Xi;Li, Zhi-Gang;Sun, Ling-Li;Sun, Shi-Li;An, Ran;Wen, Shuai;Li, Dong-Li;Li, Dong-Li;Huang, Qiu-Sheng

作者机构：

关键词： AMPK; citrus maxima; lipid deposition; tea

期刊名称：JOURNAL OF MEDICINAL FOOD （ 影响因子：2.786； 五年影响因子：2.969 ）

ISSN： 1096-620X

年卷期： 2020 年 23 卷 9 期

页码：

收录情况： SCI

摘要： Tea and citrus maxima are natural, medicinal homologous plants, typically used for making beverages, which have anticancer, antiobesity, and antioxidation properties. Green tea, yellow tea, and black tea were combined with citrus maxima to obtain green tea andCitrus maxima(GTCM), yellow tea andCitrus maxima(YTCM), and black tea andCitrus maxima(BTCM). The biochemical components of these mixtures were analyzed, and their possible effects and mechanisms on relieving liver lipid deposition were explored. The tea polyphenols, free amino acids, phenolamine ratio, and caffeine were comparable in YTCM and GTCM, being significantly higher than those in BTCM. In addition, the content of esterified catechins, nonesterified catechins, and total catechins in YTCM was significantly higher than those in GTCM and BTCM. All three mixtures ofCitrus maximatea significantly reduced lipid deposition in HepG2 cells, with GTCM and YTCM being slightly more effective than BTCM. Regarding the possible mechanism, Western blot analysis revealed that the threeCitrus maximatea mixtures could activate the AMPK/ACC signaling pathway, upregulate the expression of p-AMPK, p-ACC, and CPT-1 proteins, and downregulate the expression of SREBP1c and fatty acid synthase proteins to inhibit fat synthesis, thereby relieving lipid deposition in liver cells. In conclusion, as a novel and healthy beverage,Citrus maximatea has the potential to alleviate liver lipid deposition, and further could be responsible for obesity treatment.

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