Dissipation and residue determination of penicillin G and its two metabolites in citrus under field conditions by DSPE/UPLC-MS/MS

文献类型： 外文期刊

第一作者： Zhou, Jie

作者： Zhou, Jie;An, Jiao;Dong, Chao;Zhang, Yaohai;Zhao, Qiyang;Cui, Yongliang;Jiao, Bining;Zhou, Jie;An, Jiao;Dong, Chao;Zhang, Yaohai;Zhao, Qiyang;Cui, Yongliang;Jiao, Bining;Zhou, Jie;An, Jiao;Dong, Chao;Zhang, Yaohai;Zhao, Qiyang;Cui, Yongliang;Jiao, Bining;Zhou, Jie;An, Jiao;Dong, Chao;Zhang, Yaohai;Zhao, Qiyang;Cui, Yongliang;Jiao, Bining

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关键词： citrus; LC-MS; MS; metabolite; penicillin G; risk assessment

期刊名称：BIOMEDICAL CHROMATOGRAPHY （ 影响因子：1.902； 五年影响因子：1.809 ）

ISSN： 0269-3879

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收录情况： SCI

摘要： A rapid determination method of residual penicillin G and its two metabolites in citrus was developed and validated by dispersive solid-phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry (DSPE/UPLC-MS/MS). The samples were extracted with 80% acetonitrile and purified with octadecylsilane. High linearity was obtained with correlation coefficients (r(2)) >0.9981. The limits of quantification were 0.005-0.01 mg/kg. The recoveries of penicillin G and its metabolites spiked in blank citrus were within 76.7-107%, with relative standard deviations of 1.3-9.6%. The dissipation dynamics and distribution of penicillin G in citrus followed first-order kinetics, with half-life of 1.7-2.7 days. Penicillin G degraded easily in citrus and the metabolite was mainly penilloic acid, which can exist stably for long time. The terminal residues of penicillin G in pulp, whole citrus and peels were 0.015-0.701, 0.047-7.653 and 0.162-13.376 mg/kg, respectively. The hazard indexes for risk assessment of citrus were significantly <1, suggesting that the health risks to humans after consumption of citrus were insignificant and negligible. These results could provide necessary data for evaluating the safe and proper use of penicillin G in citrus.

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