Regulation of glutathione-dependent antioxidant defense system of grass carpCtenopharyngodon idellaunder the combined stress of mercury and temperature

文献类型： 外文期刊

第一作者： Li, Zhi-Hua

作者： Li, Zhi-Hua;Li, Ping;Li, Zhi-Hua;Wu, Yanhua

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关键词： Thermal stress; Metal; Fish; Physiological adaption; Glutathione

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：4.223； 五年影响因子：4.306 ）

ISSN： 0944-1344

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收录情况： SCI

摘要： In this study, we investigated the combined effects of temperatures fluencies and mercury (Hg) on glutathione-dependent antioxidant system in fish, by measuring the oxidative stress indicator (LPO, lipid peroxidation) and the parameters involved in the glutathione-related antioxidant defense system (GPx, glutathione peroxidase; GR, glutathione reductase; GST, glutathione S-transferase; GSH, reduced glutathione), as well as the expression of related genes in grass carp,Ctenopharyngodon idella. Fish (45.37 +/- 3.58 g) were exposed to 10 test groups, e.g., 15 degrees C with/without Hg, 20 degrees C with/without Hg, 25 degrees C with/without Hg, 30 degrees C with/without Hg, 35 degrees C with/without Hg for 4 weeks. Three-way ANOVA was used to analyze the correlation between the measured parameters and experimental conditions (water temperature, Hg exposure, exposure time, and their interactions.). Our results show that there is no interaction between mercury and low temperature, but the combined effect at high temperature has been confirmed, which indicated the glutathione-dependent enzyme system in grass carp has a complex regulatory mechanism with temperature fluctuations. In the actual field monitoring, it is necessary to consider the impact of extreme temperature on the toxicity of pollutants in the aquatic ecosystem.

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