The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

文献类型： 外文期刊

第一作者： Wang, Hui

作者： Wang, Hui;Yang, Feng;Xin, Ruihua;Cui, Dongan;He, Jiongjie;Zhang, Shidong;Sun, Yan

作者机构：

关键词： Manganese; Neurotoxicity; Gut microbiota; Inflammation

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：6.529； 五年影响因子：5.979 ）

ISSN： 0753-3322

年卷期： 2020 年 129 卷

页码：

收录情况： SCI

摘要： Manganese (Mn) exposure has been reported to cause neurodegenerative disorders. beta-Amyloid (A beta) induced Tau pathology in an NLRP3-dependent manner is at the heart of Alzheimer's and Parkinson's diseases. The gut microbiota plays a crucial role in the bidirectional gut-brain axis that integrates the gut and central nervous system (CNS) activities. In this study, we found that Mn exposure increases A beta(1-40) and Tau production in brain, and causes hippocampal degeneration and necrosis. Meanwhile, Mn exposure can stimulate neurotoxicity by increasing inflammation either in peripheral blood and CNS. Importantly, we found that transplantation of gut microbiota from normal rats into Mn exposure rats reduced A beta and Tau expression, and the cerebral expression of NLRP3 was downregulated, and the expression of neuroinflammatory factors was also downregulated. Therefore, improving the composition of gut microbiota in Mn exposure rats can attenuate neuroinflammation, which is considered as a novel therapeutic strategy for Mn exposure by remodelling the gut microbiota.

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