Astragaloside IV Extends Lifespan ofCaenorhabditis elegansby Improving Age-Related Functional Declines and Triggering Antioxidant Responses

文献类型： 外文期刊

第一作者： Zhang, Jianqin

作者： Zhang, Jianqin;Xue, Xiaoli;Qiao, Yuqi;Zhang, Fusheng;Qin, Xuemei;Li, Daqi;Wei, Qing

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关键词： astragaloside IV; Caenorhabditis elegans; antiaging; metabolomics; antioxidation

期刊名称：REJUVENATION RESEARCH （ 影响因子：4.663； 五年影响因子：4.342 ）

ISSN： 1549-1684

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收录情况： SCI

摘要： Astragaloside IV (AS-IV) is a representative component of astragaloside saponins in dried roots of Astragali Radix. Astragaloside possesses a broad spectrum of pharmacological activities, including antibacterial, anti-fibrosis, antioxidant, anti-inflammatory, and neuroprotective effects. However, the role of AS-IV in antiaging remains unclear. In this article, we studied the function of AS-IV in antiaging by using theCaenorhabditis elegans(C. elegans) model. We showed that AS-IV can prolong the lifespan ofC. elegansin a natural aging model, a paraquat injury model, and a heat stress model and improve the movement capacity of nematodes.H-1-NMR data indicate an improvement of glutamate content and a decrease in glucose in the AS-IV treatment group compared with the control. Further investigation revealed that AS-IV can induce the mRNA expression of superoxide dismutase (SOD) and catalase (CAT) genes and increase the activities of SOD and CAT in the nematode. Interestingly, AS-IV could not extend the lifespan ofsod-1,sod-2,sod-3,sod-4,sod-5,ctl-1,ctl-2,ctl-3, anddaf-16mutants. These data indicate that AS-IV prevents aging via mainly improving age-related functional declines, the antioxidant capacity of nematodes and partially modulating the insulin/insulin growth factor 1 signaling pathway activity. Our results provide new insights into how AS-IV prevents and treats aging.

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