MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells

文献类型： 外文期刊

第一作者： Ren, Tingting

作者： Ren, Tingting;Wang, Yanxue;Chen, Haotai;Wang, Kailing;Gao, Xin;Zhang, Yongguang;Sun, Yuefeng;Wang, Yanxue;Liu, Lei;Ren, Tingting;Wang, Yanxue;Chen, Haotai;Wang, Kailing;Gao, Xin;Zhang, Yongguang;Sun, Yuefeng

作者机构：

关键词： miRNAs; FMDV; Interferon

期刊名称：VIRUS RESEARCH （ 影响因子：3.303； 五年影响因子：3.445 ）

ISSN： 0168-1702

年卷期： 2020 年 286 卷

页码：

收录情况： SCI

摘要： MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/2009 influenza A virus replication by targeting viral HA and NS. However, whether microRNA ssc-miR-4331-5p (miR-4331-5p) regulates foot and mouth virus (FMDV) replication remains unclear. To explore the role of miR-4331-5p in FMDV infection, we detected the expression level of miR-4331-5p in porcine kidney (PK-15) cells. The results showed that FMDV infection directly upregulates miR-4331-5p expression, while transfection of mimics or inhibitor of miR-4331-5p promotes or inhibits FMDV replication. Further investigation clearly showed that miR-4331-5p increases FMDV replication through inhibiting type I interferon pathways. These data demonstrate that miR-4331-5p plays an important role in regulating FMDV replication.

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