Napthrene Compounds from Mycelial Fermentation Products ofMarasmius berteroi

文献类型： 外文期刊

第一作者： Yang, Ning Ning

作者： Yang, Ning Ning;Yun, Qing;Kong, Fan Dong;Xie, Qing Yi;Dai, Hao Fu;Zhou, Li Man;Zhao, You Xing;Yang, Ning Ning;Yun, Qing;Kong, Fan Dong;Xie, Qing Yi;Dai, Hao Fu;Zhao, You Xing;Yu, Zhi Fang

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关键词： Marasmius berteroi; dipolynaphthalenes; binapthrene; AChE inhibitory activity; cytotoxic activity

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

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年卷期： 2020 年 25 卷 17 期

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收录情况： SCI

摘要： The metabolites of the genusMarasmiusare diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungiMarasmius berteroi, the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A-B (1,2) and naphthone C (3), as well as 12 known compounds (4-15). Compounds1,2, and4are dimeric naphthalene compounds. Their structures were elucidated by MS, 1D and 2D NMR spectroscopic data, as well as ECD calculations. Compounds2-4and7exhibited acetylcholinesterase (AChE) inhibitory activities at the concentration of 50 mu g/mL with inhibition ratios of 42.74%, 44.63%, 39.50% and 51.49%, respectively. Compounds5and7,8showed weak inhibitory activities towards two tumor cell lines, with IC(50)of 0.10, 0.076 and 0.058 mM (K562) and 0.13, 0.18, and 0.15 mM (SGC-7901), respectively.

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