Tomenphantadenine, an unprecedented germacranolide-adenine hybrid heterodimer from the medicinal plant Elephantopus tomentosus L.

文献类型: 外文期刊

第一作者: Guo, Zhi Kai

作者: Guo, Zhi Kai;Wang, Bei;Cai, Cai Hong;Huang, Sheng Zhuo;Yuan, Jing Zhe;Mei, Wen Li;Dai, Hao Fu;Guo, Zhi Kai;Wang, Bei;Cai, Cai Hong;Huang, Sheng Zhuo;Yuan, Jing Zhe;Mei, Wen Li;Dai, Hao Fu;Guo, Zhi Kai;Wang, Bei;Cai, Cai Hong;Huang, Sheng Zhuo;Yuan, Jing Zhe;Mei, Wen Li;Dai, Hao Fu

作者机构:

关键词: Elephantopus tomentosus;Medicinal plant;Sesquiterpene lactone;Antibacterial activity

期刊名称:FITOTERAPIA ( 影响因子:2.882; 五年影响因子:3.202 )

ISSN: 0367-326X

年卷期: 2018 年 125 卷

页码:

收录情况: SCI

摘要: An unusual adenine-substituted germacrane sesquiterpene lactone, tomenphantadenine (1), has been isolated from the whole plant of Elephantopus tomentosus L. The structure of this compound was established by comprehensive spectroscopic analysis including high resolution (HR) ESI-MS, 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data. This compound features novel hybrid pattern of germacrane sesquiterpene with adenine through C-N linkage, and a possible biosynthetic pathway for it was proposed. Compound 1 showed potent antibacterial activity against the gram-positive Staphylococcus aureus and weak acetylcholinesterase (AChE) inhibitory activity.

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