Digging metagenomic data of pangolins revealed SARS-CoV-2 related viruses and other significant viruses

文献类型： 外文期刊

第一作者： Yang, Shixing

作者： Yang, Shixing;Xiao, Yuqing;Zhang, Heteng;Wang, Xiaochun;Shen, Quan;Wang, Yan;Yao, Yuxin;Liu, Qi;Zhang, Wen;Shan, Tongling;Wang, Hao

作者机构：

关键词： pangolin; phylogeny; recombination; SARS-CoV-2-related virus

期刊名称：JOURNAL OF MEDICAL VIROLOGY （ 影响因子：2.327； 五年影响因子：2.075 ）

ISSN： 0146-6615

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收录情况： SCI

摘要： Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing genetic relationship to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sendai virus, flavivirus, picornavirus, parvovirus, and genomovirus, respectively. Most of these virus genomes showed genomic recombination signals. Phylogeny based on the SARS-CoV-2-related virus sequences assembled in this study and those recently published indicated that pangolin SARS-CoV-2-related viruses were clustered into two sub-lineages according to geographic sampling sites. These findings suggest the need for further pangolin samples, from different countries, to be collected and analyzed for coronavirus to elucidate whether pangolins are intermittent hosts for SARS-CoV-2.

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