Comparative Proteomic Analysis Reveals Complex Responses toBordetella bronchisepticaInfections in the Spleen of Rabbits

文献类型： 外文期刊

第一作者： Xiao, Chenwen

作者： Xiao, Chenwen;Huang, Yee;Wei, Qiang;Liu, Yan;Ji, Quanan;Li, Ke;Bao, Guolian

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关键词： Bordetella bronchiseptica; complex responses; infections; rabbits; spleen

期刊名称：PROTEOMICS （ 影响因子：3.984； 五年影响因子：3.831 ）

ISSN： 1615-9853

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收录情况： SCI

摘要： Bordetella bronchiseptica (B. bronchiseptica)causes a respiratory disease in rabbits. To determine the proteins ofB. bronchisepticain rabbits related to the disease, differentially accumulated proteins inB. bronchiseptica-infected cells are identified by comparative proteomic analysis. Comparative proteomic analysis detects 5814 proteins and quantifies 4854 of these. Fifty eight upregulated and 38 downregulated proteins are identified in spleen tissue afterB. bronchisepticainfection of rabbits (bothp< 0.05). The significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways are ribosome, biosynthesis of amino acids, biosynthesis of amino acids, protein export, and carbon metabolism etc. (allp< 0.01). Significantly enriched KEGG pathways include 'ocu03010 ribosome' (a); 'ocu00260 glycine, serine threonine metabolism'. Analyses of control and infected spleen cells detect responses toB. bronchisepticainfection. Many differentially affected proteins are evident, and reflect different biological changes and diverse subcellular localizations between control and infected spleen cells. Infection markedly alters the expressions of proteins linked to the serine protease system, with the 'phagosome,' 'biosynthesis of amino acids,' 'glycine, serine threonine metabolism,' 'intestinal immune network for IgA production', and 'amino sugar and nucleotide sugar metabolism' associated withB. bronchisepticainfection. The result will inform studies of responses toB. bronchisepticainfections in rabbits.

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