Stress response of rainbow trout fry after exposure to an elevated concentration of carbon dioxide based on transcriptome analysis

文献类型： 外文期刊

第一作者： Chen, Yan

作者： Chen, Yan;Cheng, Bo;Chen, Yan;Yang, Xiaofei;Xu, Shaogang;Bai, Yucen;Hu, Xiaolu

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关键词： Carbon dioxide; Transcriptome; HSPs; Ubiquitin-proteasome

期刊名称：ICHTHYOLOGICAL RESEARCH （ 影响因子：1.223； 五年影响因子：1.162 ）

ISSN： 1341-8998

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收录情况： SCI

摘要： To investigate the mechanism of future predicted increases in carbon dioxide (CO2)-induced gill remolding in early life stages of fish, we evaluated physiological responses and performed transcriptome sequencing analysis of rainbow trout Oncorhynchus mykiss fry after 60 days of 1,000 ppm CO2 exposure. The malondialdehyde (MDA) content increased and key antioxidant enzymes were significantly inhibited, indicating that exposure to high CO2 may disrupt cellular redox homeostasis in the gill. The transcriptome sequencing analysis provided a list of possible stress responses of rainbow trout fry exposed to 1,000 ppm CO2. The upregulated uncoupling protein 2 and downregulated differentially expressed genes (DEGs) enriched in oxidative phosphorylation pathway tried to reduce oxidative stress. The upregulated DEGs enriched in ribosome biogenesis in eukaryotes pathway together with the induced heat shock proteins (HSPs) and ubiquitin-conjugated proteins occurred in treated fish to prevent the accumulation of aggregated proteins in gill tissue of the rainbow trout fry after the exposure of 1,000 ppm CO2.

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