gga-miR-200b-3p Promotes Macrophage Activation and DifferentiationviaTargeting Monocyte to Macrophage Differentiation-Associated in HD11 Cells

文献类型： 外文期刊

第一作者： Lin, Wencheng

作者： Lin, Wencheng;Zhou, Lianghui;Liu, Manqing;Zhang, Danmeng;Yan, Yiming;Zhang, Xiquan;Xie, Qingmei;Luo, Qingbin;Lin, Wencheng;Yan, Yiming;Xie, Qingmei;Zhou, Lianghui;Liu, Manqing;Zhang, Danmeng;Zhang, Xiquan;Luo, Qingbin;Zhou, Lianghui;Liu, Manqing;Zhang, Danmeng;Zhang, Xiquan;Luo, Qingbin;Chang, Yung-Fu

作者机构：

关键词： gga-miR-200b-3p; macrophage; activation; MMD; cytokine

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）

ISSN： 1664-3224

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) play a critical role in various biological processes through regulation of gene expression post-transcriptionally. Although miRNAs are involved in cell proliferation and differentiation in mammals, few reports regarding the effects of host miRNAs on macrophage activation and differentiation are available in birds. Here, we reported that gga-miR-200b-3p acts as a positive regulator, enhancing macrophage activation and differentiation using an avian model. We found that ectopic expression of gga-miR-200b-3p in HD11 cells enhances the amount of MHC-II-positive cells and promotes the expression of pro-inflammatory cytokines and that gga-miR-200b-3p directly targets monocyte to macrophage differentiation-associated (MMD). The inhibition of MMD by gga-miR-200b-3p enhances the activation and differentiation of HD11 cells and increases the expression of pro-inflammatory cytokines. Collectively, these findings highlight a crucial role of gga-miR-200b-3p in macrophage activation and differentiation in birds.

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