Review of psychological stress on oocyte and early embryonic development in female mice

文献类型： 外文期刊

第一作者： Zhai, Qiu-Yue

作者： Zhai, Qiu-Yue;Song, Zhenhua;Zhai, Qiu-Yue;Song, Zhenhua;Wang, Jun-Jie;Tian, Yu;Liu, Xiaofang

作者机构：

关键词： Psychological stress; Oocyte; Early embryonic development; Subfertility

期刊名称：REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY （ 影响因子：5.211； 五年影响因子：5.017 ）

ISSN：

年卷期： 2020 年 18 卷 1 期

页码：

收录情况： SCI

摘要： Psychological stress can cause adverse health effects in animals and humans. Accumulating evidence suggests that psychological stress in female mice is associated with ovarian developmental abnormalities accompanied by follicle and oocyte defects. Oocyte and early embryonic development are impaired in mice facing psychological stress, likely resulting from hormone signalling disorders, reactive oxygen species (ROS) accumulation and alterations in epigenetic modifications, which are primarily mediated by the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-ovarian (HPO) axes. The present evidence suggests that psychological stress is increasingly becoming the most common causative factor for female subfertility. Here, we review recent progress on the impact of psychological stress on female reproduction, particularly for oocyte and early embryonic development in female mice. This review highlights the connection between psychological stress and reproductive health and provides novel insight on human subfertility.

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