Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver

文献类型： 外文期刊

第一作者： Zhang, Ruifen

作者： Zhang, Ruifen;Ma, Qin;Tong, Xin;Liu, Lei;Dong, Lihong;Huang, Fei;Deng, Yuanyuan;Jia, Xuchao;Chi, Jianwei;Zhang, Mingwei

作者机构：

关键词： Rice bran; Phenolic compounds; Lipid metabolism; AMP-activated protein kinase; Adiponectin

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2020 年 73 卷

页码：

收录情况： SCI

摘要： Rice bran is a by-product of rice milling, which contains variety of nutrients, and has been reported to possess various activities. Here, we used high fat (HF) diet induced mice to investigate the effects of rice bran phenolic extracts (RBPE) on lipid metabolism. Sixteen-week intake of RBPE (200 mg/kg/d and 400 mg/kg/d) significantly improved the serum lipid profiles of HF diet-fed mice and ameliorated HF diet-induced liver steatosis. Further study showed that RBPE might regulate lipid metabolism through increasing the levels of serum adiponectin, and thereby promoting the activation of 5 ' adenosine monophosphate-activated protein kinase alpha (AMPK alpha) in liver. Taken together, RBPE might regulate lipid metabolism through adiponectin-mediated AMPK activation and the subsequent reduction of lipid biosynthesis together with the increase of fatty acid oxidation in liver. These results provide us new evidence of the health benefits of rice bran.

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