Progress in the Development of Subunit Vaccines against Malaria

文献类型： 外文期刊

第一作者： Skwarczynski, Mariusz

作者： Skwarczynski, Mariusz;Chandrudu, Saranya;Rigau-Planella, Berta;Islam, Md. Tanjir;Cheong, Yee S.;Liu, Genan;Wang, Xiumin;Toth, Istvan;Hussein, Waleed M.;Wang, Xiumin;Wang, Xiumin;Toth, Istvan;Toth, Istvan

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关键词： malaria; parasite; Plasmodium; peptide-based vaccine; clinical trials

期刊名称：VACCINES （ 影响因子：4.422； 五年影响因子：5.513 ）

ISSN：

年卷期： 2020 年 8 卷 3 期

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收录情况： SCI

摘要： Malaria is a life-threatening disease and one of the main causes of morbidity and mortality in the human population. The disease also results in a major socio-economic burden. The rapid spread of malaria epidemics in developing countries is exacerbated by the rise in drug-resistant parasites and insecticide-resistant mosquitoes. At present, malaria research is focused mainly on the development of drugs with increased therapeutic effects againstPlasmodiumparasites. However, a vaccine against the disease is preferable over treatment to achieve long-term control. Trials to develop a safe and effective immunization protocol for the control of malaria have been occurring for decades, and continue on today; still, no effective vaccines are available on the market. Recently, peptide-based vaccines have become an attractive alternative approach. These vaccines utilize short protein fragments to induce immune responses against malaria parasites. Peptide-based vaccines are safer than traditional vaccines, relatively inexpensive to produce, and can be composed of multiple T- and B-cell epitopes integrated into one antigenic formulation. Various combinations, based on antigen choice, peptide epitope modification and delivery mechanism, have resulted in numerous potential malaria vaccines candidates; these are presently being studied in both preclinical and clinical trials. This review describes the current landscape of peptide-based vaccines, and addresses obstacles and opportunities in the production of malaria vaccines.

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