Biphenyl metabolites from the patchouli endophytic fungus Alternaria sp. PfuH1

文献类型： 外文期刊

第一作者： Kong, Fan-Dong

作者： Kong, Fan-Dong;Yi, Tian-Feng;Ma, Qing-Yun;Xie, Qing-Yi;Zhou, Li-Man;Chen, Jin-Ping;Dai, Hao-Fu;Zhao, You-Xing;Yi, Tian-Feng;Wu, You-Gen;Kong, Fan-Dong;Ma, Qing-Yun;Xie, Qing-Yi;Zhou, Li-Man;Chen, Jin-Ping;Dai, Hao-Fu;Zhao, You-Xing

作者机构：

关键词： Patchouli; Pogostemon cablin; Endophytic fungus; Alternaria; Biphenyl compounds; Antibacterial activity

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2020 年 146 卷

页码：

收录情况： SCI

摘要： Patchouli is a tropical medicinal and spice crop with high economic value, and the endophytic microorganism is also one of its important components and can provide new active compounds with medicinal use. In the present study, four new biphenyl compounds named 3-O-demethylaltenuisol (1), (-)-dialtenuisol (5) and (+)-dialtenuisol (6), and altertoxin VII (9), as well as six known related compounds, were isolated from the patchouli (Pogostemon cablin) endophytic fungus Alternaria sp. PfuH1. The structures of the new compounds were elucidated from spectroscopic data, ECD spectra analysis, and ECD calculations. Compounds 5 and 6 are a pair of dimeric axially chiral enantiomers. Compounds 2, 4, and 9 showed antibacterial activities against S. agalactiae with MIC values of 9.3, 85.3, and 17.3 mu g/mL, respectively, and compound 4 also showed weak antibacterial activity against E. coli with MIC value of 128 mu g/mL.

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