Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus

文献类型： 外文期刊

第一作者： Yang, Bo

作者： Yang, Bo;Zhang, Xiaohui;Zhang, Dajun;Hou, Jing;Xu, GuoWei;Sheng, Chaochao;Choudhury, Sk Mohiuddin;Zhu, Zixiang;Li, Dan;Zhang, Keshan;Zheng, Haixue;Liu, Xiangtao

作者机构：

关键词： foot-and-mouth disease virus; immune escape; innate immune response; interferon; protein interaction; viral protein

期刊名称：PATHOGENS （ 影响因子：3.492； 五年影响因子：4.066 ）

ISSN：

年卷期： 2020 年 9 卷 9 期

页码：

收录情况： SCI

摘要： Foot-and-mouth disease virus (FMDV) causes a highly contagious vesicular disease in cloven-hoofed livestock that results in severe consequences for international trade, posing a great economic threat to agriculture. The FMDV infection antagonizes the host immune responses via different signaling pathways to achieve immune escape. Strategies to escape the cell immune system are key to effective infection and pathogenesis. This review is focused on summarizing the recent advances to understand how the proteins encoded by FMDV antagonize the host innate and adaptive immune responses.

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