MiR-4334-5p Facilitates Foot and Mouth Disease Virus Propagation by Suppressing Interferon Pathways via Direct Targeting ID1

文献类型： 外文期刊

第一作者： Wang, Yanxue

作者： Wang, Yanxue;Ren, Tingting;Chen, Haotai;Wang, Kailing;Zhang, Yongguang;Sun, Yuefeng;Wang, Yanxue;Liu, Lei;Wang, Yanxue;Ren, Tingting;Chen, Haotai;Wang, Kailing;Zhang, Yongguang;Sun, Yuefeng

作者机构：

关键词： miR-4334-5p; ID1; FMDV; interferon

期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）

ISSN：

年卷期： 2020 年 11 卷 10 期

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收录情况： SCI

摘要： Emerging evidence indicates that the host microRNAs (miRNAs) are important intracellular regulators and play pivotal roles in intricate host-pathogen interaction networks. In our previous studies, ssc-microRNA-4334-5p (miR-4334-5p) was identified as a differentially expressed miRNA in microarray-based miRNAs profiling experiment, but whether miR-4334-5p regulates foot and mouth disease virus (FMDV) propagation is less understood. Here, we demonstrated that miR-4334-5p expression level was up-regulated shortly after FMDV infection, transfection of miR-4334-5p mimics promoted, while inhibitor transfection suppressed FMDV replication correspondingly. Further bioinformatic analysis and experimental study suggested ID1 was the direct target of miR-4334-5p, suppressing FMDV replication by regulating interferon (IFN) pathways. These findings shed light on microRNAs-ID1-interferon axis in regulating FMDV replication.

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