Expression Profile of Porcine TRIM26 and Its Inhibitory Effect on Interferon-beta Production and Antiviral Response

文献类型： 外文期刊

第一作者： Huang, Hui

作者： Huang, Hui;Sharma, Mona;Zhang, Yanbing;Li, Chenxi;Liu, Ke;Wei, Jianchao;Shao, Donghua;Li, Beibei;Ma, Zhiyong;Qiu, Yafeng;Huang, Hui;Cao, Ruibing

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关键词： TRIM26; antiviral response; IFN-β poly (I; C); VSV; PRRSV

期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）

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年卷期： 2020 年 11 卷 10 期

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收录情况： SCI

摘要： TRIM26, a member of the tripartite motif (TRIM) family has been shown to be involved in modulation of innate antiviral response. However, the functional characteristics of porcine TRIM26 (porTRIM26) are unclear. In this study, we used a synthesized antigen peptide to generate a polyclonal antibody against porTRIM26 with which to study the expression and function of porTRIM26. We demonstrated that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of porTRIM26 promotes interferon (IFN)-beta production after poly (I:C) stimulation and virus infection (VSV or PRRSV). The importance of the porTRIM26-mediated modulation of the antiviral response was also shown in VSV- or PRRSV-infected cells. In summary, these findings show that porTRIM26 has an inhibitory role in IFN-beta expression and the antiviral response.

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