Expression Profile of Porcine TRIM26 and Its Inhibitory Effect on Interferon-beta Production and Antiviral Response
文献类型： 外文期刊
第一作者： Huang, Hui
作者： Huang, Hui;Sharma, Mona;Zhang, Yanbing;Li, Chenxi;Liu, Ke;Wei, Jianchao;Shao, Donghua;Li, Beibei;Ma, Zhiyong;Qiu, Yafeng;Huang, Hui;Cao, Ruibing
作者机构：
关键词： TRIM26; antiviral response; IFN-β poly (I; C); VSV; PRRSV
期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）
ISSN：
年卷期： 2020 年 11 卷 10 期
页码：
收录情况： SCI
摘要： TRIM26, a member of the tripartite motif (TRIM) family has been shown to be involved in modulation of innate antiviral response. However, the functional characteristics of porcine TRIM26 (porTRIM26) are unclear. In this study, we used a synthesized antigen peptide to generate a polyclonal antibody against porTRIM26 with which to study the expression and function of porTRIM26. We demonstrated that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of porTRIM26 promotes interferon (IFN)-beta production after poly (I:C) stimulation and virus infection (VSV or PRRSV). The importance of the porTRIM26-mediated modulation of the antiviral response was also shown in VSV- or PRRSV-infected cells. In summary, these findings show that porTRIM26 has an inhibitory role in IFN-beta expression and the antiviral response.
分类号：
- 相关文献
作者其他论文 更多>>
-
An Overview of Zika Virus and Zika Virus Induced Neuropathies
作者：Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Mustafa, Bahar E.;Mustafa, Bahar E.;Tawaab, Abdul;Hameed, Muddassar;Hameed, Muddassar;Hameed, Muddassar;Batool, Hira;Shoaib, Anam;Wei, Jianchao
关键词：neurotropic flaviviruses; zika virus; neuropathies; transmission; neuropathogenesis; prevention; vaccines; treatment; antivirals; mosquito/vector control; oncolytic; animal and cell models
-
The wheat NLR pair RXL/Pm5e confers resistance to powdery mildew
作者：Guo, Guanghao;Hou, Yikun;Zhang, Huaizhi;Lu, Ping;Li, Miaomiao;Dong, Lingli;Xie, Jingzhong;Zhu, Keyu;Li, Beibei;Dong, Lei;Yang, Yijun;Qiu, Dan;Wang, Gaojie;Zhao, Yusheng;Chen, Yuhang;Liu, Zhiyong;Guo, Guanghao;Ahn, Hee-Kyung;Zhao, He;Jones, Jonathan D. G.;Bai, Kaihong;Hou, Yikun;Li, Beibei;Dong, Lei;Liu, Zhiyong;Gong, Zhen;Han, Guan-Zhu;Wu, Qiuhong;Chen, Yongxing;Li, Wenling;Li, Hongjie;Zhang, Panpan;Yuan, Chengguo;Shi, Wenqi;Xue, Minfeng;Yang, Lijun;Yu, Dazao;Hu, Tiezhu;Liu, Zhiyong;Ahn, Hee-Kyung
关键词：wheat; powdery mildew; NLR pair; hetero-complexes; resistance mechanism
-
A compendium of 8,176 bat RNA viral metagenomes reveals ecological drivers and circulation dynamics
作者：Yan, Xiaomin;Liu, Yang;Li, Chenxi;Liu, Yuhang;Li, Nan;Sun, Yue;Yi, Le;Tu, Changchun;He, Biao;Hu, Tingsong;Zhang, Fuqiang;Huang, Zhenglanyi;Feng, Jiang;Jiang, Tinglei;Guo, Lei;Zhang, Hailin;Wu, Jianmin;Tu, Changchun
关键词：
-
GhADT5 enhances alkali stress tolerance in cotton by regulating phenylalanine-derived flavonoid biosynthesis and antioxidant defense
作者：Wang, Lidong;Zhang, Menghao;Meng, Junting;Liu, Mengyue;Meng, Yuan;Chen, Wenhua;Fan, Yapeng;Huang, Hui;Sun, Yuping;Yang, Zhining;Chen, Xiao;Wu, Fange;Song, Ruize;Wang, Shuai;Lu, Xuke;Chen, Xiugui;Zhao, Lanjie;Wang, Junjuan;Cui, Yupeng;Ye, Wuwei;Wang, Lidong;Chen, Qin;Ye, Wuwei;Nan, Hongyu;Wang, Ning;Feng, Keyun;Guang, Lijun;Zhou, Xue-Rong
关键词：Phenylalanine (phe); Flavonoid biosynthesis; Arogenate dehydratase (ADT);
GhADT5 ; Cotton (Gossypium Spp. ); Virus-induced gene silencing (VIGS); Cotton breeding -
Hatcheries' contamination: the molecular characterization and pathogenicity of Mycoplasma gallisepticum isolates in China
作者：Fang, Huanxin;Li, Qi;Li, Pei;Xu, Sixiang;Tan, Libin;Zhu, Xihui;Zheng, Xiangkuan;Tian, Rui;Qi, Zitai;Li, Chenxi;Yu, Yanfei;Zhang, Wei;Zhang, Chunyan;Qi, Zitai;Yu, Yanfei
关键词：Mycoplasma gallisepticum; Hatcheries' contamination; Pipping failure embryos; China I Clade; Vertical and horizontal transmission
-
Chronic Low-Dose Phoxim Exposure Impairs Silk Production in Bombyx mori L. (Lepidoptera: Bombycidae) by Disrupting Juvenile Hormone Signaling-Mediated Fibroin Synthesis
作者：Xie, Xinyi;Du, Xiaohua;Xie, Xinyi;Hou, Jiayin;Li, Meng;Liu, Zhiyu;He, Mengai;Li, Chenxi;Chen, Liezhong
关键词：silkworm; phoxim; chronic toxicity; silk gland; juvenile hormone
-
Development of a Noninfectious Japanese Encephalitis Virus Replicon for Antiviral Drug Screening and Gene Function Studies
作者：Yang, Yang;Zheng, Jiayang;Lin, Yafang;Zhang, Hailong;Zhang, Junjie;Li, Zongjie;Liu, Ke;Li, Beibei;Shao, Donghua;Qiu, Yafeng;Ma, Zhiyong;Wei, Jianchao;Zhang, Yan;Zhao, Qianming
关键词：Japanese encephalitis virus; replicon; green fluorescent protein; antiviral drug screening; RNA replication
