Swine acute diarrhea syndrome coronavirus replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway

文献类型： 外文期刊

第一作者： Zhang, Jiyu

作者： Zhang, Jiyu;Zhang, Liaoyuan;Shi, Hongyan;Feng, Shufeng;Feng, Tingshuai;Chen, Jianfei;Zhang, Xin;Han, Yuru;Liu, Jianbo;Wang, Yiming;Ji, Zhaoyang;Jing, Zhaoyang;Liu, Dakai;Shi, Da;Feng, Li

作者机构：

关键词： Swine acute diarrhea syndrome coronavirus; (SADS-CoV); ERK pathway; Viral replication; Apoptosis

期刊名称：VIROLOGY （ 影响因子：3.513； 五年影响因子：3.479 ）

ISSN： 0042-6822

年卷期： 2022 年 565 卷

页码：

收录情况： SCI

摘要： Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered enteric coronavirus. We have previously shown that the caspase-dependent FASL-mediated and mitochondrion-mediated apoptotic pathways play a central role in SADS-CoV-induced apoptosis, which facilitates viral replication. However, the roles of intracellular signaling pathways in SADS-CoV-mediated cell apoptosis and the relative advantages that such pathways confer on the host or virus remain largely unknown. In this study, we show that SADS-CoV induces the activation of ERK during infection, irrespective of viral biosynthesis. The knockdown or chemical inhibition of ERK1/2 significantly suppressed viral protein expression and viral progeny production. The inhibition of ERK activation also circumvented SADS-CoV-induced apoptosis. Taken together, these data suggest that ERK acti-vation is important for SADS-CoV replication, and contributes to the virus-mediated changes in host cells. Our findings demonstrate the takeover of a particular host signaling mechanism by SADS-CoV and identify a potential approach to inhibiting viral spread.

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