Nationwide genomic surveillance reveals the prevalence and evolution of honeybee viruses in China

文献类型： 外文期刊

第一作者： Li, Nannan

作者： Li, Nannan;Wu, Jiangli;Kang, Weipeng;Xu, Shufa;Li, Cixiu;Li, Juan;Zhou, Hong;Ji, Jingkai;Li, Cixiu;Hu, Tao;Li, Juan;Zhou, Hong;Ji, Jingkai;Shi, Weifeng;Holmes, Edward C.;Shi, Weifeng

作者机构：

关键词： Honeybees; Ectoparasite mites; Meta-transcriptomics; Virus landscape; Evolution; Virus discovery

期刊名称：MICROBIOME （ 影响因子：15.5； 五年影响因子：19.4 ）

ISSN： 2049-2618

年卷期： 2023 年 11 卷 1 期

页码：

收录情况： SCI

摘要： Background The economic and environmental value of honeybees has been severely challenged in recent years by the collapse of their colonies worldwide, often caused by outbreaks of infectious diseases. However, our understanding of the diversity, prevalence, and transmission of honeybee viruses is largely obscure due to a lack of large-scale and longitudinal genomic surveillance on a global scale.Results We report the meta-transcriptomic sequencing of nearly 2000 samples of the two most important economic and widely maintained honeybee species, as well as an associated ectoparasite mite, collected across China during 2016-2019. We document the natural diversity and evolution of honeybee viruses in China, providing evidence that multiple viruses commonly co-circulate within individual bee colonies. We also expanded the genomic data for 12 important honeybee viruses and revealed novel genetic variants and lineages associated with China. We identified more than 23 novel viruses from the honeybee and mite viromes, with some exhibiting ongoing replication in their respective hosts. Together, these data provide additional support to the idea that mites are an important reservoir and spill-over host for honeybee viruses.Conclusions Our data show that honeybee viruses are more widespread, prevalent, and genetically diverse than previously realized. The information provided is important in mitigating viral infectious diseases in honeybees, in turn helping to maintain sustainable productive agriculture on a global scale.

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