Genetic diversity of H9N2 avian influenza viruses in poultry across China and implications for zoonotic transmission
文献类型： 外文期刊
第一作者： Yang, Jing
作者： Yang, Jing;Sun, Ju;Li, Jiaming;Tian, Tian;Wang, Lixia;Dong, Jia;Wu, Mingjia;Liu, Yun;Shang, Ruoyu;Wang, Yanqing;Yuan, Kunpeng;Ran, Lin;Liu, Wenjun;Gao, George F.;Bi, Yuhai;Yang, Jing;Wu, Mingjia;Wang, Yanqing;Ran, Lin;Liu, Wenjun;Gao, George F.;Bi, Yuhai;Yang, Jing;Sun, Ju;Li, Jiaming;Bi, Yuhai;Li, Juan;Li, Shan;Dong, Hui;Li, Juan;Li, Shan;Shang, Ruoyu;Sun, Ju;Tian, Tian;Wang, Lixia;Liu, Yun;Yuan, Kunpeng;Tian, Wenxia;Bi, Yuhai;Fu, Guanghua;Huang, Yu;Yang, Yongchun;Yang, Yongchun;Lu, Xuancheng;Li, Delong;Hu, Dongfang;Sun, Honglei;Liu, Jinhua;Shi, Weifeng;Shi, Weifeng;Gao, George F.;Bi, Yuhai
作者机构：
期刊名称：NATURE MICROBIOLOGY （ 影响因子：19.4； 五年影响因子：20.7 ）
ISSN： 2058-5276
年卷期： 2025 年 10 卷 6 期
页码：
收录情况： SCI
摘要： Nationwide surveillance of avian influenza viruses (AIVs) in live poultry markets across China has occurred since 2014, providing a resource for AIV prevalence and genetic diversity studies. Here we report that 3,237 of 18,425 samples from poultry were AIV positive (17.57%) between 2019 and 2023, with H9N2 being the dominant subtype. We developed an automated phylogeny-based nomenclature system to classify genetic clades of the dominant H9N2 lineage, the BJ94 lineage. Using this model, we found that ten haemagglutinin (HA) sub-subclades cocirculated in poultry and showed antigenic variation. In addition, 99.46% and 96.17% of H9N2 AIVs in 2021-2023 possessed human-receptor binding-related HA-L226 and human MxA-resistance-related NP-N52 mutations, respectively. H9N2 strains with these two mutations preferred human-type receptors and increased replication in human cells in vitro, regardless of the presence of PB2-V/K/E627. Moreover, H9N2 AIVs containing HA-L226, PB2-V/K627 and NP-N52 were transmitted from infected to naive guinea pigs and ferrets through direct contact and respiratory droplet. This highlights the potential zoonotic risks of H9N2 AIVs.
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