Fabrication of gelatin microspheres containing ammonium hydrogen carbonate for the tunable release of herbicide

文献类型： 外文期刊

第一作者： Liu, He

作者： Liu, He;Zhang, Zheng;Li, Jiaxin;Zang, Wanyu;Yang, Qing;Yang, Jun;Yang, Qing;Yang, Qing

作者机构：

关键词： Gelatin microspheres; Controlled release; Temperature responsive; NH4HCO3; Herbicide

期刊名称：BIOTECHNOLOGY LETTERS （ 影响因子：2.461； 五年影响因子：2.457 ）

ISSN： 0141-5492

年卷期： 2021 年 43 卷 9 期

页码：

收录情况： SCI

摘要： The major challenge in utilizing pesticides lies in identifying the precise application that would improve the efficiency of these pesticides and decline their environmental and health hazards at the same time. Such application requires the development of specific formulations that enable controlled, stimuli-responsive release of the pesticides. Gelatin is a relatively cheap material characterized by temperature-sensitivity and abundant amino acid groups, which makes it suitable for the storage and controlled release of pesticides. In this study, gelatin microspheres were prepared by emulsion and cross-linking, then they were loaded with 2,4-dichlorophenoxyacetic acid sodium (2,4-D Na) as a model herbicide. To achieve temperature-tunable release of 2,4-D Na from the microspheres, NH4HCO3 was added to the formulations at different concentrations. The prepared formulations were characterized by SEM, FTIR, and size distribution analyzes, and their drug loading capacities were determined. Based on bioassay experiments, the 2,4-D Na-NH4HCO3-loaded gelatin microspheres can effectively control the spread of dicotyledonous weeds. Therefore, the strategy proposed herein can be used to develop novel, effective herbicide formulations.

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