The Genomic Characterization of Equid Alphaherpesviruses: Structure, Function, and Genetic Similarity

文献类型： 外文期刊

第一作者： Liu, Diqiu

作者： Liu, Diqiu;Zhao, Xiaoyang;Wang, Xiaojun

作者机构：

关键词： equid alphaherpesvirus; genomic structure; function; comparative analysis; future research

期刊名称：VETERINARY SCIENCES （ 影响因子：2.3； 五年影响因子：2.4 ）

ISSN：

年卷期： 2025 年 12 卷 3 期

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收录情况： SCI

摘要： Equine herpesvirus 1 (EHV-1), EHV-4, EHV-8, and EHV-9, are classified within the subfamily Alphaherpesvirinae and are recognized as causative agents of respiratory, urogenital, and neurological disorders in horses. These viruses, collectively referred to as alpha EHVs, exhibits both unique and shared characteristics in terms of host interaction, pathogenesis, epidemiology, and immune evasion, which arise from both the identities and discrepancies among respective genomic homologs. The genomic architecture of alpha EHVs is similar to other members of the same subfamily, such as well-known HSV-1, VZV, and PRV. However, research on the molecular mechanisms underlying alpha EHV infection and immune response remains significantly less advanced compared to studies on human, porcine, and bovine herpesviruses. This paper systematically describes the genomic structure, function, and genetic similarities of alpha EHVs and conducts a comparative analysis of selected alpha EHVs through pairwise sequence alignments of nucleotides and amino acids. This review offers an extensive synthesis of the current understanding related to the study of alpha EHVs, highlighting the challenges and potential solutions for future research endeavors.

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