Systematic assessment of oat fi -glucan catabolism during in vitro digestion and fermentation

文献类型： 外文期刊

第一作者： Bai, Junying

作者： Bai, Junying;Fan, Mingcong;Qian, Haifeng;Li, Yan;Wang, Li;Li, Tingting;Zhang, Wenhui

作者机构：

关键词： fi-Glucan; Digestion; Fermentation; Microbiome; Metabolome

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2021 年 348 卷

页码：

收录情况： SCI

摘要： fi-Glucan as a component of grain cell walls is consumed daily. However, little is known about whether fi-glucan is influenced by the gastrointestinal environment. In this study, we aim to investigate the integrated metabolic process of cereal fi-glucan. In vitro simulated digestion and fermentation combined with microbiome and metabolome analysis were used to profile the metabolism of fi-glucan. Intriguingly, we found that fi-glucan was not hydrolyzed by digestive enzymes but partially degraded by gastric acid environment during in vitro digestion. Moreover, fi-glucan was utilized by gut microbiota to produce acetate, propionate and butyrate, concurrently, the relative abundance of Lactobacillus significantly increased and Escherichia-Shigella significantly decreased. The correlation analysis between metabolomics datasets and microorganisms revealed that fi-glucan catabolism was also accompanied by amino acid catabolism and linoleic acid biosynthesis. Our study offered a forceful basis for the further exploration of the role of fi-glucan and gut microbiota in host health.

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[1]Systematic assessment of oat fi -glucan catabolism during in vitro digestion and fermentation. Bai, Junying,Fan, Mingcong,Qian, Haifeng,Li, Yan,Wang, Li,Li, Tingting,Zhang, Wenhui. 2021

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