Short-term exposure of Cannabidiol on Zebrafish (Danio Rerio): Reproductive Toxicity

文献类型： 外文期刊

第一作者： Li, Lin

作者： Li, Lin;Fan, Bei;Zhang, Yifan;Zhao, Mengying;Wang, Fengzhong;Li, Minmin;Kong, Zhiqiang;Simal-Gandara, Jesus

作者机构：

关键词： Cannabidiol; Zebrafish; Reproductive Toxicity; Gonad; Apoptosis

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：5.8； 五年影响因子：5.4 ）

ISSN： 0944-1344

年卷期： 2023 年 30 卷 30 期

页码：

收录情况： SCI

摘要： Cannabidiol (CBD), a medically active component of hemp, is a popular ingredient in healthcare and personal-care products. The increasing demand for CBD and the legalization of hemp growth may promote chronic exposure of non-target organisms to CBD. In this study, the reproductive toxicity of CBD was investigated on adult zebrafish. With CBD treatment, female zebrafish spawned less with higher natural mortality and malformation rates. Both female and male zebrafish showed a decreased gonadosomatic index with an increased percentage of pre-mature oocytes and sperm and had an increased hepatosomatic index with decreased content of vitellogenin. The value of estrogen/testosterone (E2/T) decreased in female zebrafish and increased in male zebrafish. Sex hormone synthesis genes were downregulated in ovaries and upregulated in testicles, except for cyp11a, in contrast to the other genes. Apoptosis-related genes were upregulated in the zebrafish brain, gonad, and liver. These results show that CBD might damage the reproductive function by inducing an apoptotic response, further inhibiting zebrafish reproductive ability.

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