Transcriptional and Post-Transcriptional Regulation of Autophagy

文献类型： 外文期刊

第一作者： Ma, Qiuqin

作者： Ma, Qiuqin;Gan, Zhending;Tian, Ling;Ma, Qiuqin;Li, Kang;Tian, Ling;Ma, Qiuqin;Tian, Ling;Long, Shihui;Li, Kang;Tettamanti, Gianluca;Tettamanti, Gianluca

作者机构：

关键词： autophagy; regulatory mechanisms; transcription; ncRNA; RNA methylation

期刊名称：CELLS （ 影响因子：7.666； 五年影响因子：7.677 ）

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年卷期： 2022 年 11 卷 3 期

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收录情况： SCI

摘要： Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. In general, autophagy is synergistically governed at the RNA and protein levels. The upstream transcription factors trigger or inhibit the expression of autophagy- or lysosome-related genes to facilitate or reduce autophagy. Moreover, a significant number of non-coding RNAs (microRNA, circRNA, and lncRNA) are reported to participate in autophagy regulation. Finally, post-transcriptional modifications, such as RNA methylation, play a key role in controlling autophagy occurrence. In this review, we summarize the progress on autophagy research regarding transcriptional regulation, which will provide the foundations and directions for future studies on this self-eating process.

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