Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597

文献类型： 外文期刊

第一作者： Chen, Meng

作者： Chen, Meng;Tang, Wei;Wang, Min;Chen, Yihua;Guo, Zhengyan;Chen, Meng;Tang, Wei;Wang, Min;Chen, Yihua;Guo, Zhengyan;Chen, Meng;Tang, Wei;Wang, Min;Chen, Yihua;Guo, Zhengyan;Cao, Zhenju

作者机构：

期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：3.424； 五年影响因子：3.066 ）

ISSN： 0021-8820

年卷期： 2022 年 75 卷 3 期

页码：

收录情况： SCI

摘要： Septacidin is an adenine nucleoside antibiotic with antifungal and antitumor activities. During the efforts to construct a better septacidin producer, we obtained a high yield strain S. albus 1597 by putting the biosynthetic gene cluster (BGC) of septacidin under the control of the constitutive strong promoter ermE*. S. albus 1597 could produce new septacidin congeners SEP-538 and SEP-552 with shorter fatty acyl chains. Moreover, SEP-624 with an unprecedented hydroxylated fatty acyl chain was also isolated from this titre improved strain, enriching the diversity of septacidins. SEP-552 showed moderate inhibitory effects against Epidermophyton floccosum 57312 with MIC value 62.5 mu M, while SEP-538 and SEP-624 only exhibited weak antifungal activities. The structure-activity relationship investigation revealed that the antifungal activity of septacidins is significantly influenced by the length of and the decoration on their fatty acyl chains.

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