Pickering emulsions constructed on the basis of nanostructured lipid carriers: Effect of carrier models and volume fractions

文献类型： 外文期刊

第一作者： Liu, Dian

作者： Liu, Dian;Feng, Jin;Nasiru, Mustapha Muhammad;Zhang, Jing;Li, Chunyang;Nasiru, Mustapha Muhammad;Zhu, Hequan;Xu, Cunfa;Li, Chunyang

作者机构：

关键词： Nanostructured lipid carriers; Pickering emulsions; Inversion; Stability; Simulated digestion

期刊名称：JOURNAL OF MOLECULAR LIQUIDS （ 影响因子：6.0； 五年影响因子：5.6 ）

ISSN： 0167-7322

年卷期： 2024 年 397 卷

页码：

收录情况： SCI

摘要： Three types of curcumin-loaded nanostructured lipid carriers with a single layer (S-NLCs), double layer (D-NLCs) and composite layer (C-NLCs) were used as stabilizers for the preparation of Pickering emulsions. Visual observations showed that the NLCs stabilized the Pickering emulsions at different addition volume fractions. The emulsions produced had approximate particle size and showed an inversion of the emulsions stabilized by DNLCs and C-NLCs as the additional fraction of NLCs was increased to 50%. Contact angles and interfacial viscoelasticity showed a better wetting of D-NLCs with a superior ability to reduce surface tension at the oil-water interface. Pickering emulsions stabilized at a 50% volume ratio (PD5) showed the highest storage and centrifugal stability. Simulated in vitro digestion studies showed the presence of delayed lipid digestion of Pickering emulsions, resulting in the incomplete release of curcumin and lower bioavailability than NLCs under the same conditions.

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