Virtual screening and in vitro validation of methane inhibitor-Fraxin

文献类型： 外文期刊

第一作者： Xiao, Li

作者： Xiao, Li;Liu, ZiHao;Zhou, MengTing;Guo, Jian;Nan, XueMei;Tang, XiangFang;Xiong, BenHai;Xiao, Li;Guo, Jian;Xiong, BenHai

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关键词： Fraxin; Rumen vitro fermentation; Methane inhibitor; Methane production; Virtual screening

期刊名称：ANIMAL FEED SCIENCE AND TECHNOLOGY （ 影响因子：2.7； 五年影响因子：3.1 ）

ISSN： 0377-8401

年卷期： 2025 年 327 卷

页码：

收录情况： SCI

摘要： The production of methane (CH4) poses a major challenge to both livestock and the environment, in particular contributing to the greenhouse effect, so reducing CH4 emissions is urgent. In this study, methyl-coenzyme M reductase (MCR) was used as a target to screen natural product libraries, identify potential natural CH4 inhibitors, and then verify their inhibitory effects on MCR and decreased in vitro CH4. The results showed that fraxin and MCR scored well. In the follow-up verification, fraxin showed significant inhibitory activity on MCR, significantly decreased in vitro CH4 production (P = 0.010), and significantly increased DMD (P = 0.049). The inhibition effect of 1 mg/gDM was the best, and the inhibition rate was 10.85 %. In this study, we found that fraxin can be used as a new feed additive that can inhibit CH4.

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