Bio-mineralization of virus-like particles by metal-organic framework nanoparticles enhances the thermostability and immune responses of the vaccines

文献类型： 外文期刊

第一作者： Teng, Zhidong

作者： Teng, Zhidong;Hou, Fengping;Bai, Manyuan;Li, Jiajun;Wang, Jun;Wu, Jinen;Ru, Jiaxi;Ren, Mei;Sun, Shiqi;Guo, Huichen;Guo, Huichen;Hou, Fengping;Guo, Huichen

作者机构：

期刊名称：JOURNAL OF MATERIALS CHEMISTRY B （ 影响因子：7.571； 五年影响因子：6.788 ）

ISSN： 2050-750X

年卷期： 2022 年 10 卷 15 期

页码：

收录情况： SCI

摘要： Virus-like particle (VLPs) vaccines have been extensively studied due to their good immunogenicity and safety; however, they highly rely on cold-chain storage and transportation. Nanotechnology of bio-mineralization as a useful strategy has been employed to improve the thermal stability and immunogenicity of VLPs. A zeolitic imidazole framework (ZIF-8), a core-shell structured nanocomposite, was applied to encapsulate foot-and-mouth disease virus (FMDV) VLPs. It was found that the ZIF-8 shell enhanced the heat resistance of VLPs and promoted their ability to be taken up by cells and escape from lysosomes. The VLPs-ZIF-8 easily activated antigen-presenting cells (APCs), triggered higher secretion levels of cytokines, and elicited stronger immune responses than VLPs alone even after being treated at 37 degrees C for 7 days. This platform has good potential in the development of VLP-based vaccine products without transportation.

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