Facile One-Pot Assembly of a Versatile Photoactive Nanozyme for Highly Efficient Antibacterial Therapy

文献类型： 外文期刊

第一作者： Chen, Yingying

作者： Chen, Yingying;Ma, Kang;Liang, Meijuan;Dong, Pei;Wang, Hong;Yu, Shanshan;Wang, Fuan;Chen, Yingying;Sun, Jianwei;Kwok, Ryan T. K.;Lam, Jacky W. Y.;Tang, Ben Zhong;Chen, Yingying;Sun, Jianwei;Kwok, Ryan T. K.;Lam, Jacky W. Y.;Tang, Ben Zhong;Liang, Meijuan;Gao, Yuhui;Tang, Ben Zhong;Wang, Fuan

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关键词： biofilms; catalytic therapy; diabetic infections; nanozyme; photodynamic therapy

期刊名称：SMALL （ 影响因子：12.1； 五年影响因子：12.5 ）

ISSN： 1613-6810

年卷期： 2025 年 21 卷 16 期

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收录情况： SCI

摘要： Conventional combinational antibacterial therapy requires the complicated assembly of multiple components that might cause a premature leak of therapeutic agents. Thus the one-pot assembly of highly integrated multifunctional antibacterial agents is highly desirable for treating multidrug-resistant (MDR) bacteria. Herein, the vancomycin-derived carbon dots (Van-CDs) are facilely developed as a compact and powerful multifunctional photodynamic nanozyme platform that achieves the augmented reactive oxygen species (ROS) generation for accelerating bacterial elimination. By residual recognition groups of vancomycin, the red emissive Van-CDs gain a specific affinity toward bacteria with a high binding constant of 20 L g-1, manifesting a superior bacteria-imaging ability. Meanwhile, Van-CDs are encoded with an excellent peroxidase-mimicking (POD) activity for mediating the H2O2-activated evolvement of center dot OH, and also endowed with intrinsic photodynamic property for simultaneously producing singlet oxygen (1O2). Surprisingly, the photodynamic Van-CDs nanozyme possesses an auxiliary photothermal feature, which enables the photothermal imaging-guided hyperthermia-reinforced antibacterial therapy in vivo. Furthermore, a subcutaneous abscess model is established to validate their pronounced biofilm eradication and wound healing acceleration in vivo through the Van-CDs-promoted collagen deposition. Taken together, the present all-in-one compact photodynamic carbon-derived nanozyme with multiple intrinsic therapeutic functions represents a promising and competitive candidate for treating diabetic infections of clinical research.

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