Phenolic profile, antioxidation and anti-proliferation activity of phenolic-rich extracts from Sanghuangporus vaninii

文献类型： 外文期刊

第一作者： Gao, Hong

作者： Gao, Hong;Yin, Chaomin;Li, Chen;Li, Yuhong;Shi, Defang;Fan, Xiuzhi;Yao, Fen;Wu, Wenjing;Gao, Hong;Li, Jiangtao;Yin, Chaomin

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关键词： Sanghuangporus vaninii; Phenolic profile; Polyphenols; Antioxidative activity; Antiproliferative activity

期刊名称：CURRENT RESEARCH IN FOOD SCIENCE （ 影响因子：6.3； 五年影响因子：6.3 ）

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年卷期： 2023 年 6 卷

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收录情况： SCI

摘要： In this study, phenolic-rich extracts from Sanghuangporus vaninii (SHE) were prepared, the phenolic profile and main phenolic compound content of SHE were studied by UPLC-Orbitrap-MS, and the antioxidant and antiproliferation activities of SHE were evaluated. The results showed that the total polyphenol content and the total flavonoid content of SHE were 42.420 & PLUSMN; 0.011 mg GAE/g EW and 8.504 & PLUSMN; 0.205 mg RE/g EW, respectively. Moreover, 14 phenolic acids and 8 flavonoids in SHE were identified, among which, the major polyphenols were protocatechualdehyde (394.68 & mu;g/g), protocatechuic acid (196.88 & mu;g/g), caffeic acid (96.11 & mu;g/g), L-phenylalanine (12.72 & mu;g/g) and (+)-taxifolin (8.59 & mu;g/g). SHE showed strong radical scavenging, anti-lipid peroxidation and anti-DNA damage capacity in vitro. SHE could effectively induce HepG2 cell apoptosis via the caspases-dependent mitochondrial apoptotic pathway and arrest the cell cycle in the G0/G1 phase. The present study suggested that S. vaninii could be a valuable source of natural antioxidative and antiproliferative ingredients.

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