Phylogenetic and Structural Analysis of Porcine Circovirus Type 2 from 2016 to 2021 in Jilin Province, China
文献类型： 外文期刊
第一作者： Chen, Si
作者： Chen, Si;Li, Xue;Zhang, Liying;Zheng, Jiawei;Yang, Lin;Niu, Guyu;Zhang, Huimin;Ren, Linzhu;Ren, Ying;Qian, Jing;Sun, Changjiang
作者机构： Jilin Univ, Coll Anim Sci, Key Lab Zoonoses Res, Minist Educ, 5333 Xian Rd, Changchun 130062, Peoples R China;Jilin Univ, Publ Comp Educ & Res Ctr, 5333 Xian Rd, Changchun 130062, Peoples R China;Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Peoples R China;Jilin Univ, Coll Vet Med, 5333 Xian Rd, Changchun 130062, Peoples R China
关键词： porcine circovirus type 2 (PCV2); molecular epidemiology; epitope; mutation
期刊名称：MICROORGANISMS （ 2022影响因子：4.5； 五年影响因子：4.8 ）
年卷期： 2023 年 11 卷 4 期
收录情况： SCI
摘要： Porcine circovirus disease (PCVD) caused by porcine circovirus type 2 (PCV2) is widely distributed in pig farms. Up until now, nine genotypes of PCV2, PCV2a to 2i, have been identified in diseased pigs worldwide. This study analyzed 302 samples collected in the Jilin Province of China from 2016 to 2021, followed by genetic analysis of the PCV2 isolates. Meanwhile, the antigen epitopes, amino acid mutations, 3D structure of the PCV2 isolates and commercially available vaccine strains were evaluated and compared. The results showed that the predominant genotypes of PCV2 were PCV2b, followed by PCV2e and PCV2d in Jilin Province during 2016-2021. Although mutations were detected in the isolates, no recombination occurred in the PCV2 isolates, indicating a stable genotype of PCV2 in Jilin Province during these years. Moreover, the B cell epitopes in the Cap and Rep proteins of eighteen PCV2 isolates and T cell epitopes in the Cap of the isolates were changed compared to three currently used vaccine strains. The mutations in the Cap and Rep proteins did not affect their spatial conformation. Therefore, bivalent or multivalent vaccines with different genotypes of PCV2 might improve the protective effect of vaccines.
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