Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

文献类型： 外文期刊

第一作者： Liu, Ming

作者： Liu, Ming;Li, Guoliang;Wan, Xinru;Li, Hongjun;Zhang, Zhibin;Liu, Ming;Zhang, Zhibin;Liu, Ming;Wang, Yan-Ling;Yu, Caixia;Du, Zhenglin;Zhang, Bing;Yu, Caixia;Du, Zhenglin;Zhang, Bing;Yu, Caixia;Du, Zhenglin;Zhang, Zhichao;Wang, Meng;Zhang, Zhichao;Song, Mingjing;Sun, Xiuping;Pialek, Jaroslav;Jacob, Jens;Lu, Jiqi;Cong, Lin;Zhang, Hongmao;Wang, Yong;Li, Guoliang;Zhang, Zhibin;Feng, Zhiyong;Wang, Dawei;Wang, Zuoxin;Wang, Zuoxin

作者机构：

关键词： Mus musculus; Domestication; Positively selected gene; Genome sequencing; Alternative splicing

期刊名称：GENOME BIOLOGY （ 影响因子：17.906； 五年影响因子：20.367 ）

ISSN： 1474-760X

年卷期： 2022 年 23 卷 1 期

页码：

收录情况： SCI

摘要： Background The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the genetic mechanism of laboratory mouse domestication remains unknown due to lack of adequate genomic sequences of wild mice. Results We analyze the genetic relationships by whole-genome resequencing of 36 wild mice and 36 inbred strains. All classical inbred mice cluster together distinctly from wild and wild-derived inbred mice. Using nucleotide diversity analysis, Fst, and XP-CLR, we identify 339 positively selected genes that are closely associated with nervous system function. Approximately one third of these positively selected genes are highly expressed in brain tissues, and genetic mouse models of 125 genes in the positively selected genes exhibit abnormal behavioral or nervous system phenotypes. These positively selected genes show a higher ratio of differential expression between wild and classical inbred mice compared with all genes, especially in the hippocampus and frontal lobe. Using a mutant mouse model, we find that the SNP rs27900929 (T>C) in gene Astn2 significantly reduces the tameness of mice and modifies the ratio of the two Astn2 (a/b) isoforms. Conclusion Our study indicates that classical inbred mice experienced high selection pressure during domestication under laboratory conditions. The analysis shows the positively selected genes are closely associated with behavior and the nervous system in mice. Tameness may be related to the Astn2 mutation and regulated by the ratio of the two Astn2 (a/b) isoforms.

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