MoS2 quantum dots as fluorescent probe for methotrexate detection

文献类型： 外文期刊

第一作者： Yang, Like

作者： Yang, Like;Ge, Jia;Ma, Demiao;Tang, Jinlu;Li, Zhaohui;Wang, Hongqi

作者机构：

关键词： Methotrexate; MoS(2 )quantum dots; Inner filter effect; Fluorescence; Biosensor

期刊名称：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY （ 影响因子：4.831； 五年影响因子：4.073 ）

ISSN： 1386-1425

年卷期： 2022 年 279 卷

页码：

收录情况： SCI

摘要： Herein, we developed a unique fluorescence biosensor for methotrexate assay based on MoS(2 )quantum dots, which were synthesized in one step using sodium molybdate and cysteine as raw materials. The fluorescence of MoS(2 )QDs could be quenched when encountered with methotrexate, which was attributed to the inner filter effect (IFE). Furthermore, this present IFE-based method showed the linearity between the MoS(2 )QDs fluorescence intensity and the methotrexate concentration in the range of 0.05-1 mu M with the LOD of 42 nM. The practical applicability of this strategy was successfully demonstrated by detecting methotrexate in real samples. Results indicated that the proposed method could be a promising sensing platform for methotrexate analysis.

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